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Using an LPS-free, endotoxin-free peptide helps reduce confounding variables in growth-factor signaling, receptor-binding, and metabolic pathway studies, allowing observed effects to be attributed more accurately to IGF-1 LR3 activity rather than contaminants

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Moreover, the resting heart rate variability (HRV) parameters also differed in ME/CFS patients, with a higher low frequency power of HRV (LFP) and a lower high frequency power of HRV (HFP)