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Key mechanisms include: Activation of neurons in the area postrema and nucleus tractus solitarius in the brainstem Enhanced satiety signaling through distinct pathways from GLP-1 mechanisms Slowed gastric emptying via calcitonin receptor-mediated effects Reduced food reward signaling and decreased โ€œfood noiseโ€ through central appetite centers Studies in knockout mouse models confirmed that cagrilintideโ€™s weight loss effects depend specifically on AMY1R and AMY3R presence, demonstrating receptor-specific mechanismsโด

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[Google Scholar] 23.United States National Library of Medicine

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