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Standard research protocols include: Dose: 300–600 mcg subcutaneous injection daily Timing: Morning injection on an empty stomach (fasted state enhances fat-oxidation effects) Cycle length: 12–24 weeks (most observe progressive results over 8–12 weeks) For joint/cartilage research: 300 mcg daily near the affected joint Reconstitution: Bacteriostatic water

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Individuals Taking Certain Medications: Some medications, like proton pump inhibitors (PPIs) for acid reflux or metformin for diabetes, can interfere with B12 absorption