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The resulting peptide has a nearly identical 3D spatial arrangement of functional groups as the original—maintaining target binding affinity—but is unrecognizable to proteases that cleave L-amino acid peptide bonds

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A marked depletion of beneficial taxa was identified, including a significant reduction in Ligilactobacillus—a probiotic genus important for mucosal immunity—as well as a pronounced decrease in Butyrivibrio, a key butyrate producer essential for gut barrier integrity, and a substantial decline in [Eubacterium]_siraeum_group, which is involved in SCFA production