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To fill this gap, we performed an extensive literature search in the PubMed database, focusing on original research articles, experimental studies, clinical trials, and reviews related to the association between OS and canine diseases

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As IKK-β is the direct upstream kinase that phosphorylates IκB-α, leading to its degradation, we next examined whether decreased TNFα-induced IκB-α phosphorylation by H 2 O 2 treatment was due to its effects on IKK-β activity