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Abbreviations AgRP agouti-related peptide BUP bupropion bupropion-SR bupropion sustained release CART cocaine- and amphetamine-regulated transcript DNP dinitrophenol exenatide-LAR exenatide long-acting release GH growth hormone GLP-1 glucagon-like peptide-1 GOAT ghrelin O -acyltransferase HbA1c Hemoglobin A1c HGF hepatocyte growth factor 11β-HSD1 11β-hydroxysteroid dehydrogenase type 1 IAPP islet amyloid polypeptide KLH heyhole limpet hemocyanin MMP matrix metalloprotease NAD nicotinamide adenine dinucleotide NPY neuropeptide tyrosine NTX naltrexone OXM oxyntomdulin PP pancreatic polypeptide PYY peptide tyrosine tyrosine PBA 4-phenyl butyric acid POMC pro-opiomelanocortin PPAR-γ peroxisome proliferator-activated receptor-γ PGC-1α peroxisome proliferator-activated receptor-γ coactivator PPA phenylpropanolamine RSV resveratrol SSRI selective serotonin reuptake inhibitor SIRT1 sirtuin-1 SNAC sodium N -[8-(2-hydroxybenzoyl) amino] caprylate TUDCA tauroursodeoxycholic acid VEGF vascular endothelial growth factor Footnotes FINANCIAL AND COMPETING INTERESTS DISCLOSURE Michael A