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Key benefits Why people compare it 1 Promotes hippocampal neurogenesis with 80% increase in aged mouse models 2 Reduces tau phosphorylation at AT8 and PHF-1 epitopes relevant to Alzheimer's 3 Improves spatial memory and learning as measured by Morris water maze 4 BBB-permeable at ~415 Da unlike full-length CNTF at 23 kDa 5 Oral bioavailability enabling chronic dosing via drinking water in studies 6 Decreases neuroinflammation (reactive astrocytes and activated microglia) 7 Reduces oxidative stress markers (4-HNE, 8-OHdG) in hippocampus 8 Disinhibits BDNF via LIF pathway blockade for sustained neurotrophic support Deep research About P21 (P021) P21 (also designated P021) is a small modified tetrapeptide with the structure Ac-DGGL-NH2 (Ac-Asp-Gly-Gly-Leu-NH2), designed as a neurotrophic compound derived from the biologically active region of Ciliary Neurotrophic Factor (CNTF)

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