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And it is after RBD binding to the host cell receptor (ACE2) that the sequential cleavage of S-protein at the S1/S2 and S2’ cleavage sites causes an irreversible conformational change in the S2 subunit, which subsequently initiates membrane fusion with the host cell

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GH-B2 also showed high halotolerance and maintained nearly maximal activity up to at least 2 M NaCl and KCl (Supplementary Fig