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Research has found that exposing renal tubular epithelial cells to various concentrations of CaOx crystal solution results in a significant increase in the expression of ferroptosis-related proteins such as p53, ACSL4, transferrin receptor (TRC), and TF as the concentration of CaOx crystals increases

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These data could explain, at least in part, why we found lower eGFR levels in relation to the GCLC rs1555903 SNP in the non-exposed but not in the exposed group (Table 4)