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In addition, intracellular scaffold proteins interface with the actin cytoskeleton, linking transmembrane tight junction proteins to the cytoskeleton and subsequently acting as a molecular target for tight junction dysregulation in various pathways, including the Zot and zonulin pathways, which both involve the dysregulation of tight junction proteins to induce alterations in intestinal permeability (7, 11–15)
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The membrane attack complex of complement causes severe demyelination associated with acute axonal injury
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