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Within approved clinical trial settings, the preparation of injectable investigational medicinal products (IMPs) must comply with Good Clinical Practice (GCP), the trial protocol, and local aseptic compounding policies

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However, because green leafy vegetables are the primary dietary source of phylloquinone and because they are usually part of a balanced diet, high phylloquinone consumption may simply be an indicator of healthy eating habits, which may — rather than phylloquinone itself — account for all or part of the association reported in observational studies (56)