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Therefore, in the present study, using a segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) that remained incompletely healed in all control rabbits for 6 weeks (assessed in 2-week intervals), pentadecapeptide BPC-157 was further studied (either percutaneously given locally [10 μg/kg body weight] into the bone defect, or applied intramuscularly [intermittently, at postoperative days 7, 9, 14, and 16 at 10 μg/kg body weight] or continuously [once per day, postoperative days 7–21 at 10 μg or 10 ng/kg body weight])