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Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions - Zhang - 2014 - Journal of Pineal Research - Wiley Online Library

Operating as a ligand for IGF1R, LR3 IGF-I binds to the alpha subunit, initiating the activation of intrinsic tyrosine kinase activity, autophosphorylating tyrosine residues in the beta subunit

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