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Long-Lasting Pigmentation Maintenance : Melanotan II provides prolonged melanin retention even after cessation of administration, attributed to its stable receptor binding and extended activation of melanogenic pathways

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Future translational efforts should pursue several directions: first, conducting deep-phenotyping trials in biopsy-confirmed MASH patients, using positron emission tomography to quantify hepatic glucose uptake and correlating these findings with intrahepatic insulin signaling (e.g., p-AKT)