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In the case of statins, both simvastatin (0.1–2.0 μM) and lovastatin (0.5–10 μM) have demonstrated the ability to inhibit differentiation into adipocytes and shunt mesenchymal formation into osteoblasts by decreasing the expression of pro-adipocyte transcription factor (PPAR-γ2) and increasing the expression of pro-osteoblast transcription factors (runx2 and osteocalcin promoter) (Li et al., 2003
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